Reconstitution of Medications for Injection.
Some medications will become unstable in solution over time. You may see these medications manufactured as dry powders.
Prior to administration of these medications, an appropriate diluent (sterile water, normal saline, and so forth) must be added. The term used to describe the process of adding the diluent to the medication is reconstitution.
The diluent is added to the dry powder. For example, the QD Syringe draws 2 ml of diluent which is added to a dry vial of 1 gram of Mefoxin, the resulting withdrawable volume is immediately delivered to the patient at the bedside.
The Quick Draw Syringe
( QD Syringe) is a truly universal multi-purpose reconstitution syringe, offering three methods of performance over traditional stand-alone devices.
AnestaWeb, Inc. Medical Division - 2011
The QD Syringe helps to safely streamline medication recostitution. It is designed to reduce the number of individual pieces, thereby saving time, reducing costs as well as providing safety to healthcare providers.
It features two cannulas in one shield; one blunt steel cannula for syringe filling, a plastic cannula for safe split-septum access and a multi-purpose tip for all hub attachments such as needles and IV devices once safety shield is activated for continued syringe use.
QD Syringe is used in Customized Procedure Kits for the Emergency and Health Care industries where bedside medication reconstitution is necessary.
Point-of-Use Drug Reconstitution Systems
Greystone Associates, Jan 2010
The inherent instability of biological drugs is a limitation that has a direct impact on the drug delivery sector. Therapeutic proteins must either be stored under special conditions or formulated to retain their efficacy from the time of manufacture until they are dispensed. Liquid protein drugs require refrigeration until dispensed – a distribution strategy referred to as the ‘Cold Chain’. Alternatively, proteins can be formulated as powders (lyophilization). Lyophilized proteins must be reconstituted prior to injection. Lyophilized drugs are sold with reconstitution vial systems, or packaged with special injection devices (e.g., pens, needle-free injectors, two-part syringes) that allow reconstitution to take place in the device prior to injection. As biological drugs continue to grow in terms of therapeutics and total prescriptions, the impact of specialty devices will increase.